I'm resurrecting this thread in part cause this scene freaked me out a ton when I was a kid, but also cause I can't remember where it was from and don't want to create the millionth thread just to satisfy my curiosity about where I saw it.
Anyways, I have a suspicion that it may be from V, but I'm not sure. I am pretty sure it involved the slow and subtle take over of our planet by creatures that replaced people we know. The scene that freaked me out so much when I was younger was of a kid traveling in the back of a station wagon with his parents. I think something that his parents say confirms the suspicion that they aren't really his family anymore, but he's trapped in the car and doesn't want to let on that he knows. So, he writes a little sign on a piece of paper and holds it to the window to passing cars (one of which may have been filled with nuns), but I don't think anyone takes him seriously.
My memory of it is pretty hazy at this point, but it scared the hell out of me for a long time. Something about the switch of parents from protectors to inescapable threat is creepy.