Not much left for me to suggest, as most of my faves have been mentioned. I might think of other stuff later, but with only a couple of minutes:
As far as superheroes go, I'd add Peter David's current run on X-Factor (and its predecessor, the Madrox miniseries). It's gotten a bit sidetracked by Civil War and such, but at its core it's a fun detective series that makes engaging use of mutant abilities.
I know no one likes Bendis anymore (well, apart from the people who buy his books), but I still get a kick out of Powers when it comes out. No question, though, its first couple of years were its strongest.
J. Michael Straczynski deservedly takes flack for his work on Spider-Man and the FF, but when he plays outside of that sandbox, he does some pretty gripping superhero stuff, though none of his series have really had satisfying conclusions. Rising Stars was drawn out by some legal battles, but even if the last few issues felt rushed, there is great reading in the first couple of trades. He then did a thoughtful, powerful reinvention of Marvel's Squadron Supreme called Supreme Power. Unfortunately, when Marvel moved it from their adults-only MAX line to the more PG-13 Marvel Knights imprint (renaming it Squadron Supreme), it lost a lot of its steam (and he seemed to lose interest), and kind of drifted away. Howard Chaykin's about to revive the title, so we'll see how that goes. JMS' latest project, The Twelve, is an outstanding Golden-Age-heroes-in-the-modern-world tale that's about halfway through at this point, so it's too early to say how it will turn out. Not only has it been very good so far, but the art by Chris Weston is absolutely off the charts. And JMS is also currently writing the best run that Thor has had since Walt Simonson.
Ed Brubaker's on a roll at Marvel right now, with Daredevil, Captain America (which hasn't featured Cap in the past year), and his revamp (with Jeff Parker) of Iron Fist, bringing a legacy of pulp adventure to the cheesy 70's hero.
For non-superhero reading, let me throw in Strangers in Paradise-- not only some of the best relationship writing that American comics has seen, but writer/artist Terry Moore's command of facial expression and body language is the equal of anyone working today.
