This is an amazing book, but I really can't imagine why anyone would want it filmed. There's no protagonist, very little connective tissue between the parts, and the main theme is basically "chaos and death". Thinking about the parts you'd have to excise to make a coherent narrative (To begin with, "The Part About The Crimes" - the most essential part of the book, "The Part About Fate", and "The Part About Amalfitano") leaves you with virtually nothing. I suppose you could tell the story of the three professors and the story of Hans Reiter and tie it in with the arrest of his nephew, but that's doing a massive disservice to the narrative and the metaphor of the novel.
Put another way, 2666 worked its way into my head like few novels before. It's ominous in unspeakable ways - and the reviews, which struggle mightily to describe WHY the book deserves the praise it receives, seem to agree with this. There's the meta-narrative of a brilliant, troubled mind raging against a death that's coming too soon by writing the bleakest possible takedown of the living world. There's the succinct summary of the atmosphere of living at the end of one century and the beginning of the next. There's the incredible feeling of dread at the constant encroachment of capitalism and the free market and the effect it has on the people who are unprepared for its arrival. But, despite how much I love it, it's so, so unfilmable. It should remain in the form it was created.