For me? I'd have to say my top moment in cinema is from the film AGORA, which is also my top film of the year. Throughout the entire film the monotheists have been violently opposed to enlightened thought and science, which they feel is in opposition to the principals found in the bible (basically summed up as 'God did it, and if you ask questions you're questioning god.. which of course means we must stone you'). Though the fact the earth was round was common knowledge to the educated in that great city of Alexandria (one of the last holdouts from the creeping Christian influence that had corrupted the Romans), the Christians regard such teachings as "pagan lies". When at last they storm the Library at Alexandria, they cravenly set about destroying the entirety of the collected wisdom of humanity, ripping scrolls from the shelves and burning them in a great bonfires. It's a holocaust of knowledge that sets humanity back for 1500 years, and they perpetrate it without remorse -- or perhaps worse, without an understanding of just how monstrous their actions are. Amenebar shoots this dispassionately, with forlorn, wistful music used to score their pitiful rampage. As they gleefully toss papyrus into the air, the camera follows the scrolls up, and then inverts, turning back over to look at the world upside down. The scrolls are now falling up towards the floor, and we're reminded of the fact that the truths they were so intent on destroying are immutable and can't be erased with religious zeal. Earlier in the film a Christian scoffs at the idea of a round earth: "How come the people on the sides don't slide off?!"
As the camera turns upside down the modern audience can only look at these religos and feel a kind of pity. They can destroy the library, but the earth is round and there is no "up" or "down" in space. They can try to fight the truth, but they can't change reality