I've always had a soft spot for Desperate Measures. It's pretty close to being an actual, good movie. And yes, Keaton is the main reason I have so much good will for the film. The car chase is pretty good too (and not all that over-the-top either). There are definitely some script problems, but I've seen lesser action movies get passes on that sort of thing.
As far as Keaton's career goes, I thought Game 6 was pretty good. He actually directed The Merry Gentleman, which I've never seen (it's streaming on Netflix). The reviews were solid for that one. Also, he signed a contract with HBO, which could either lead to movies or a TV series.