This is a really great interview. I would not have expected you to treat it like a goof, but because you didn't, you got far more interesting answers than a lot of other people who've had the guy's time. The thing about this weird ass movie is, when you first see it, you're tearing it apart (Lisa), MST-style - but once you get a sense of this guy - and the sincerity in him - it's hard to hate. You kinda' get to a place where you realize that he had a lot to say about life and love and human interaction, but his reach exceeded his grasp.
I always got the sense that the script for the film was part of a longer and more detailed version of the story (he told me as much when I met him), and that the story was more than a little autobiographical (which he emphatically, defensively denied - which, to me, means I was totally right), and so when he decided to create a script, he had maybe lived with this passion project for so long, that he adapted it in ill-considered shorthand. He didn't have a well-developed sense of what needed to be there for an audience - but he knew EXACTLY what he needed to have in it to satisfy his own artistic notions.
Then, of course, things go wrong on a set - you never get what you really want...
So sure, The Room is a mess, but it comes from this real place where Wiseau really wanted to say something, he just lacked the tools.
And I know people will think I'm a douche for saying so, but I definitely think the guy could be properly used in film.