I'll second Concrete, it's totally not what you'd expect it to be based on its' premise. Fragile Creatures, if I remember correctly, drew from Chadwick's real life experiences working on the set of Masters of the Universe - a fact that makes the comic that much more interesting.
Some of my favorites:
American Splendor
Invincible (Kirkman's best title, IMHO.. and one of the most fun and consistent superhero books)
Lone Wolf and Cub - a must read for those into samurai/Japanese culture
Planetary
Conan - both the classic Marvel titles as well as the current Dark Horse titles, which are pretty faithful to Howards stories
The Boys - It gets a lot of flack, but I have a blast with every issue
Northlanders - historical fiction set in the varying northern European/Nordic/Viking setting.
Persepolis
Palestine
The Tick
Sandman (duh)
ElfQuest (original Pini run, up through Kings of the Broken Wheel... solid fantasy with great artwork and a lot of soul.. which got watered down when other creators were invited into the mix
Crossed - Brutal stuff. Good "zombie" action.
Preacher
Watchmen (duh)
Dork (IMHO, Dorkins funniest work.. much better than Milk & Cheese!)
Bone!
Buddha by Osamu Tezuka. A semi-biography of The Buddha by the guy who brought you AstroBoy. How can you lose?
Maus
Locke & Key - Cool little horror/thriller by Joe Hill
Usagi Yojimbo - Still as great as it was when it started long ago. Using Japanese mythology and culture gives Sakai a seemingly never-ending pool of inspiration for his ronin bunny.
I'm only recently breaking down and giving mainstream superhero books a shot, but it's pretty hit or miss. I really enjoyed Blackest Night and Brightest Day, but have mixed feelings on Green Lantern as a whole. Likewise, I've been reading some of the Ultimate X-Men/Ultimate Spider-Man series and find myself enjoying them for what they are. There's just so much history in the Marvel/DC universes and not enough consistency.





















