Final list. Separated into groups of 10 because I find it can make lists easier to absorb.
1. Diner (1982) d. Barry Levinson
2. Ghostbusters. (1984) d. Ivan Reitman
3. Caddyshack (1980) d. Harold Ramis.
4. Airplane! (1980) d. Jim Abrahams, David Zucker, Jerry Zucker
5. This is Spinal Tap (1984) d. Rob Reiner
6. Midnight Run (1988) d. Martin Brest
7. Lost In America (1985) d. Albert Brooks
8. Raising Arizona (1987) d. The Coens
9. The Princess Bride (1987) d. Rob Reiner
10. Fletch (1985) d. Michael Ritchie
11. A Fish Called Wanda (1988) d. Charles Crichton
12. Top Secret! (1984) d. Jim Abrahams, David Zucker, Jerry Zucker
13. Better Off Dead (1985) d. Savage Steve Holland
14. Little Shop of Horrors (1986) d. Frank Oz
15. Beetle Juice (1988) d. Tim Burton
16. Trading Places (1983) d. John Landis
17. Planes, Trains & Automobiles (1987) d. John Hughes
18. Real Genius (1985) d. Martha Coolidge
19. Ferris Bueller's Day Off (1986) d. John Hughes
20. Back to School (1986) d. Alan Metter
21. Roxanne (1987) d. Fred Schepisi
22. The Blues Brothers (1980) d. John Landis
23. Revenge of the Nerds (1984) d. Jeff Kanew
24. ¡Three Amigos! (1986) d. John Landis
25. Evil Dead II (1987) d. Sam Raimi
26. Dirty Rotten Scoundrels (1988) d. Frank Oz
27. The 'burbs (1989) d. Joe Dante
28. Back to the Future (1985) d. Robert Zemeckis
29. A Christmas Story (1983) d. Bob Clark
30. National Lampoon's Vacation (1983) d. Harold Ramis
31. Clue (1985) d. Jonathon Lynn
32. When Harry Met Sally… (1989) d. Rob Reiner
33. Coming to America (1988) d. John Landis
34. Pee Wee's Big Adventure (1985) d. Tim Burton
35. Who Framed Roger Rabbit (1988) d. Robert Zemeckis
36. 48 Hrs. (1982) d. Walter Hill
37. Broadcast News (1987) d. James L. Brooks
38. Used Cars (1980) d. Robert Zemeckis
39. Bill Cosby: Himself (1983) d. Bill Cosby
40. Amazon Women on the Moon (1987) d. Joe Dante, John Landis, Robert K. Weiss
41. Scrooged (1988) d. Richard Donner
42. Ruthless People (1986) d. Jim Abrahams, David Zucker, Jerry Zucker
43. Tootsie (1982) d. Sydney Pollack
44. Richard Pryor Live On The Sunset Strip (1982) d. Joe Layton
45. The Adventures of Bob & Doug McKenzie: Strange Brew (1983) d. Rick Moranis, Dave Thomas
46. Monty Python's The Meaning of Life (1983) d. Terry Jones, Terry Gilliam
47. Time Bandits (1981) d. Terry Gilliam
48. The Naked Gun (1988) d. Jim Abrahams, David Zucker, Jerry Zucker
49. Hollywood Shuffle (1987) d. Robert Townsend
50. Big Trouble In Little China (1986) d. John Carpenter
51. Withnail and I (1986) d. Bruce Robinson
52. Risky Business (1983) d. Paul Brickman
53. Shock Treatment (1981) d. Jim Sharman
54. After Hours (1985) d. Martin Scorsese
55. Stripes (1981) d. Ivan Reitman
56. Real Men (1987) d. Dennis Feldman
57. Innerspace (1987) d. Joe Dante
58. My Favorite Year (1982) d. Richard Benjamin
59. Tapeheads (1988) d. Bill Fishman
60. Heathers (1988) d. Michael Lehmann
61. Repo Man (1984) d. Alex Cox
62. The Sure Thing (1985) Rob Reiner
63. The Man With Two Brains (1983) d. Carl Reiner
64. Say Anything… (1989) d. Cameron Crowe
65. Valley Girl (1983) d. Martha Coolidge
66. An American Werewolf in London (1981) d. John Landis
67. The Gods Must Be Crazy (1981) d. Jamie Uys
68. Eddie Murphy Delirious (1983) d. Bruce Gowers
69. Bagdad Cafe (1987) d. Percy Adlon
70. Weird Science (1985) d. John Hughes
71. Rustlers' Rhapsody (1985) d. Hugh Wilson
72. I'm Gonna Git You Sucka (1988) d. Keenen Ivory Wayans
73. Johnny Dangerously (1984) d. Amy Heckerling
74. Night Shift (1982) d. Ron Howard
75. Down And Out In Beverly Hills (1986) d. Paul Mazursky
76. Fast Times at Ridgemont High (1982) d. Amy Heckerling
77. Big (1988) d. Penny Marshall
78. Local Hero (1983) d. Bill Forsyth
79. Get Crazy (1983) d. Allan Arkush
80. Dunyayi Kurtaran Adam (Turkish Star Wars) (1982) d. Cetin Inanc
81. Hopscotch (1980) d. Ronald Neame
82. Stir Crazy (1980) d. Sidney Poitier
83. Summer School (1987) d. Carl Reiner
84. Student Bodies (1981) d. Mickey Rose
85. Things Change (1988) d. David Mamet
86. National Lampoon's Christmas Vacation (1989) d. Jeremiah S. Chechik
87. Porky's (1982) d. Bob Clark
88. The Purple Rose of Cairo (1985) d. Woody Allen
89. Something Wild (1986) d. Jonathan Demme
90. Sixteen Candles (1984) d. John Hughes
91. Bill and Ted's Excellent Adventure (1989) d. Stephen Herek
92. Brazil (1985) d. Terry Gilliam
93. Space Balls (1987) d. Mel Brooks
94. Mystery Train (1989) d. Jim Jarmusch
95. Biloxi Blues (1988) d. Mike Nichols
96. Tin Men (1987) d. Barry Levinson
97. Gremlins (1984) d. Joe Dante
98. Flash Gordon (1980) d. Mike Hodges
99. Encounters of the Spooky Kind (1980) d. Sammo Hung
100. UHF (1989) d. Jay Levey
Honorable mentions
(Movies that aren't quite good enough or films we just plain forgot about.)
9 to 5 (1980) d. Colin Higgins
Beverly Hills Cop (1984) d. Martin Brest
Bronco Billy (1980) d. Clint Eastwood
Into the Night (1985) d. John Landis
The Goonies (1985) d. Richard Donner
Married to the Mob (1988) d. Jonathan Demme
Modern Romance (1981) d. Albert Brooks
Police Acadamy (1984) d. Hugh Wilson
Running Scared (1986) d. Peter Hyams
Spies Like Us (1985) d. John Landis
Throw Mamma from the Train (1987) d. Danny DeVito
Unfaithfully Yours (1984) d. Howard Zieff
War of the Roses (1989) d. Danny DeVito
I've added 9 to 5 because that would have been my next choice had the list not ended before I got online today.
The Goonies is also my addition just because I have an irrational love for the movie even though it doesn't hold up to viewings as an adult