Daytripper, the ten issue Vertigo mini-series from 2010 by Fabio Moon and Gabriel Ba, is the best graphic novel I have read in years. It will change your life.
I read this last year, and really enjoyed it. The series follows the main character, Bras, through different points in his life from childhood to old age, the hook being thatWarning: Spoiler! (Click to show)
at the end of every issue, he dies. Each issue then picks up at a different point in time, with events in his life having taken a different turn.
Anyway, agreed, it's really well done. Writing and art are both top-notch, and it's very moving at points.
It's the story of a guy's life, with no real SF or fantasy elements...except the narrative structure is such that there IS a surreal element to it, but it's not "fantasy" per se. It's really hard to describe this without giving anything away. Maybe I'd compare it to Annie Hall or something, where there's a lot of screwing around with meta-narrative that makes it seem magical realist, even though every individual issue is mundane enough.
Putting that aside, it's the story of a guy who wants to be a writer, to get out from the shadow of his novelist dad, but who ends up writing obituaries instead. Death is a big theme.
And yeah, it's kind of a brilliant comic. As you can probably see, there's no real "hook" (well, there is, but I don't want to give it away) but trust me, it's worth reading, if only for Moon and Ba's artwork. (For the record, that looked a lot more like Moon's artwork than Ba's to me, but apparently they both worked on it.)
Ooof, yeah. Apologies, Prankster! I'll edit in a spoiler tag.
It's not so much a "twist" in the "...and he was a ghost all along!" sense, though. I'd heard about the central conceit in promo material and interviews before I picked up the book, and it's probably what drew me to it initially.