So, my take: I enjoyed this film, and more so, I think, than the 2002 version. Garfield succeeds in making the character his own (for one thing, he's properly skinny), and Stone is just magnetic anytime she's onscreen: her WTF reaction just before they kiss is a brilliant moment.
I like that Martin Sheen isn't forced to recite the Responsibility Line verbatim, and I'm impressed by the streamlining or recontextualizing of other elements in Webhead's traditional origin story. Special props to the luchador poster.
I'm not so hot on the Lizard- -I feel like we got him in this film because Sam Raimi already had him in development for whatever sequel he actually wanted to make. And poor Rhys Ifans gets some of the worst scenes in the film: first, when he has to listen to Irrfan Khan* mangle a load of potentially useful exposition, then when he's recovering from his first transformation and talking all secret-villainous and double-meaningy to Peter, and most awkwardly the bit where he's ranting at himself in ADR.
The biggest stumbling-block for me is the endless franchise-building; the innumerable references to plot elements that can only be played out or embellished in future films. It's kind of hilarious at the end when the filmmakers pan across Peter's bulletin-board and basically admit flat-out that they left a lot of stuff hanging. Prediction: we'll find out that Peter was genetically-engineered (cloned?) from the start and that's why he's a genius and that's why the spider bite didn't just kill him. Insane Fanwank: the prominent featuring of a Rear Window poster in Peter's room will foreshadow a series of story-specific Hitchcock posters, culminating with Vertigo as Peter, grieving for Gwen, meets a redhead also played by Emma Stone.
Meanwhile, what's the deal with The Man In the Shadows? I don't understand why so many people are jumping to the conclusion that it's somehow Norman Osborn, except that it's the shortest possible jump. But the character we glimpse seems to be a ghost or a hallucination, and there's specific emphasis on his fine black hat (a Homburg, I think), not something I associate with the once and future Gobby. Any hardcore comics fans know who this is actually supposed to be?
*P.S. Khan's only in this movie because of Spider-Man's unique appeal in India, right?