I think it should be laid to rest for about 20 - 30 years and wait for, Bragga with his endless boring fucking time travel episodes that hit the reset key at the end of the episode go in to retirement and Berman to be kicked off the Paramount lot.
The thing with Trek is that its incredibly formulaic, and while the writers were eventually working around the formula with TNG and DS9, Voyager and Enterprise have been nothing but rehashed plots and hackneyed elements from better days of Trek, hell they even declawed the Borg through overuse....
At the end of the day Trek needs something fresh, some kind of fresh angle, but currently its so bogged down with its own back story, mythos, rules, regs & technobable "Sir if I remodulate the pan agnostic flanger through the warp field alkaseltza, plink fizz EM band harmonica jelly wizz conduate, then I should be able to create a cackle, raggy, ibuprophen transformer paracetamol aspidistra ray" that constrain the shows drama, meaning that its just not interesting anymore.....
The best idea for taking Trek forward, just playing devils advocate here and suggesting a comeback for the show, would be to take Gene Rodenberrys other show idea which was clearly going to be Trek until he died and someone else got hold of it, which was Andromeda.
Now bare with me, because straight off the bat I know Andromeda is utter crap, but look at the concept and see if you couldnt apply that to Trek.
The Commonwealth is clearly the Federation in all but name, then due to the Commonwealths closest ally to the humans, the Niezchians, who you could say are either Khan style genetic superhumans or in the case of co founders of the Commonwealth, the Vulcans perform a coup. During this coup, one commonwealth ship survives the war by accidentally sitting it out due to time dilation caused by a black hole. Some x amount of years later the ship is freed and the crew come to terms with the fact that the universe is very different now and the Commonwealth has been dead for years.
Now as I say take that and stick it in to the Trek universe, with no Federation, no prime directive, no everyone is happy clappy, in touch with their feelings, always understanding crew members, they'd have to adjust to the collapse of everything they upheld... Then just add a writer with the balls to run with the concept and just pick and choose elements that worked with Trek, the ensemble dynamic, the exploration, the relevent issue of the day built in to the plot and weave in some darkness and dramatic conflict which almost all the series lack....